Ultra B12-Folate - 90 capsules

Ultra B-12 Folate by Designs for Health contains 2 coenzyme forms of methylated B12 with natural folates.

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Product Details


This unique supplement contains B12 in both its coenzyme forms. These forms offer unique nutritional support for MS, hepatitis, neuropathies, and Bell's Palsy. Folic acid is one of the most important and clinically valuable B vitamins. It is important to the division of cells in the body, and is essential during times of growth, such as pregnancy. [1] Vitamin B-12 also known as the “anti-fatigue vitamin” is essential for the metabolism of nerve tissue and crucial for the health of the entire nervous system. B-12 aids in the formation of red blood cells, increases energy levels, helps iron function better, and stimulates the utilization of proteins, fats and carbohydrates. Folic acid is useful in the treatment and prevention of heart disease as it effectively lowers homocysteine levels. It aids in red blood cell production, assists in amino acid conversions, and is used in the formation of the nucleic acids for RNA and DNA. Hence, it is valuable to support wound and gut healing, cancer, cervical dysplasia, hot flashes, low sex drive in menopausal women, estrogen replacement, psoriasis, restless leg syndrome, chronic fatigue, and HIV infection.

Benefits of Vitamin B-12 include

  • Elevated Homocysteine
  • Multiple Sclerosis
  • Bursitis
  • Nerve Damage
  • Asthma and Allergies
  • Nerve Pain
  • Blood Pressure
  • Infertility
  • Alzheimer’s Disease
  • Heart Disease
  • Osteoporosis
  • Anemia
Benefits of Folic Acid include
  • Birth defects prevention
  • Healthier looking skin & new skin cells
  • Formation and function of white blood cells
  • Depression
  • Cervical dysplasia, cervical cancer, birth control pills, fatigue, lactation, and osteoporosis
  • Heart disease prevention
  • Wound and gut healing
  • Colitis
  • Gastrointestinal problems
  • Restless leg syndrome
  • HIV infection

Warning on Synthetic Folic Acid: Read about the important differences and safety concerns to consider between Synthetic Folic vs Natural Folate (DFH uses Natural Folate in their products).

Per DFH:
The NatureFolate is a concentrated vegetable powder that contains a variety of naturally occurring folates. The material is not however either standardized to nor assayed for any one specific folate. Therefore we have added or supplemented the vegetable powder with the folate, folinic acid which is one of the two primary folates found in nature. The other is 5-MTHF. This folate though, when manufactured, can occur in both the S and R forms, the S (also known as L) form being the preferred form. This is what we use in the standalone product L-5MTHF.

Vitamin B12 (cobalamin) works with folic acid in many body processes including the synthesis of DNA, red blood cells, and the maintenance of the myelin sheath that surrounds nerve cells. A B12 deficiency results in pernicious anemia, impaired nerve function, and impaired mental function.

Folic acid is one of the most essential nutrients for all normal cell growth and replication. Folic acid has major role in DNA synthesis and without it cells do not divide properly. The benefit of folic acid (along with B12) supplementation is a result of reducing body concentrations of homocysteine. Homocysteine has a hand in a variety conditions, including atherosclerosis, multiple sclerosis, osteoporosis, and mental decline to name a few. Folic acid deficiency is linked to depression, atherosclerosis, and birth defects. Folic acid supplementation should always include B12 because folic acid can hide an underlying B12 deficiency, which can result in permanent nerve damage.

Conditions for B12-Folate
  • AIDS
  • Asthma
  • Bell’s Palsy
  • Depression
  • Diabetic neuropathy
  • Hepatitis
  • HIV
  • Homocysteinemia
  • Impaired mental function
  • Mercury toxicity
  • Sulfite sensitivity
  • Low sperm counts
  • Multiple Sclerosis
  • Tinnitus

    Multiple Sclerosis is an autoimmune demyelization disease. Myelin, the protective sheath around nerves, is destroyed and a common cause is a higher than average homocysteine level. Elevated homocysteine, as a result of folic acid and B12 deficiency, is toxic to the nervous system and has been linked to depression, schizophrenia, multiple sclerosis, Parkinson’s disease, Alzheimer’s disease and cognitive decline in the elderly. People with multiple sclerosis don't metabolize B12 properly [1], which leaves them more vulnerable to nerve damage. Several studies have shown that vitamin B12 levels in serum, red blood cells, and CNS are low in multiple sclerosis.

    A cobalamin deficiency impairs the immune system’s ability to fight off germs and viruses. Viral hepatitis has been treated for years with vitamin B12 as it aids the immune system in decreasing viral damage.

    Neuropathies/Bell’s Palsy
    Nerve damage created by diabetes or elevated homocysteine benefits from vitamin B12 and folate supplementation. Aggressive cobalamin therapy eases pain from nerve damage of diabetic neuropathy. [2] An insufficient intake of folic acid can result in numbing, tingling pain in the legs and arms.

    Elevated Homocysteine
    Hyperhomocysteinemia is due to enzyme dysfunction, lifestyle or nutritional deficiencies. A genetic disorder causing elevated homocysteine affects only 1:200,000 births. Homocysteine is an intermediate product of methionine metabolism. If this pathway for methionine metabolism is compromised by nutrient deficiencies (vitamin B12, folic acid) homocysteine levels rise and have been implicated in cardiovascular disease, neural tube defects, spontaneous abortion, renal failure, non-insulin dependent diabetes, rheumatoid arthritis, osteoporosis, and neuropsychiatric disorders. Here is the pathway of homocysteine methylation to produce methionine: Homocysteine→Coenzyme B12→Methionine

    Vitamin B12 and folic acid deficiency can cause depression which is most prevalent in the elderly. [3] Vitamin B12 declines with age and deficiency is found in 3 to 42 percent in those 65 and over. However, anyone suffering from vitamin B12 deficiency can have symptoms of depression. Correcting an underlying vitamin B12 deficiency can result in improvement mood.

    Below normal B12 levels are common in HIV disease and continue fall in most in patients. B12 may help to predict those patients whose disease will progress most rapidly. [4] Vitamin B12 deficiency is seen in ten to thirty-five percent of all HIV-positive patients, as a result of decreased intake, reduced absorption, or antagonism by the drug AZT. [5]

    One of a Kind
    Ultra B12 Folate was created by Designs for Health as the only supplement that contains Vitamin B12 in both of its coenzyme forms. These coenzyme forms offer unique nutritional support for MS, hepatitis, neuropathies, and Bell’s Palsy.



Each capsule contains:

  • Vitamin B12 (as adenosylcobalamin and methylcobalamin) 2000 mcg
  • Folates (NatureFolate blend) 400 mcg


Other Ingredients: Microcrystalline cellulose, magnesium stearate, dicalcium phosphate.

Does Not Contain wheat, yeast, soy, gluten, eggs, dairy, corn, artificial colors, flavors, sugars, or preservatives.

Additional Info

Additional Info

Variant 1
Recommended Use As a dietary supplement, take one to three capsules per day with meals or as directed by your health care practitioner.
Serving Size 1 capsule
Additional Notes These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.


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