TRF 150 30 capsules

TRF 150™ (Tissue Regeneration Factor) features 150 mg of Cyplexinol™, a bone-derived protein/collagen complex containing Body/Bone Morphogenetic Proteins (BMPs) and key growth factors naturally contained in bone, such as Transforming Growth Factor Beta (TGF-β), Insulin-like Growth Factor (IGF), Platelet Derived Growth Factor (PDGF), and Basic Fibroblast Growth Factor (bFGF).

Clinical effects of the results of supplemental BMPs are validated with multiple studies.  TRF 150™ is effective in helping to maintain bone strength and joint homeostasis, as well as the pathways which cause cartilage degradation because it features thoroughly researched Cyplexinol™. The proteins (found in bone and bovine milk) contained in Cyplexinol™ have been shown to activate the bone and cartilage-forming process. TRF’s Cyplexinol™ exerts its effect on bone via increasing bone formation and reducing bone resorption.

This allows TRF 150™ to address the processes which lead to cartilage degradation, as well as the ensuing pain and inflammation caused by arthritis and other degenerative joint conditions.   TRF 150™ should be a first line defense for any stage of osteoporosis, any type of fracture and for any condition in need of joint or cartilage repair.  Consider pairing it with OsteoForce™ (for bones) or ArthroSoothe™ (for joints).

Cyplexinol™ studies conclude:

• Cyplexinol is a bone anabolic agent  (tissue regenerating)
• Bone volume of rats increased by 78% given Cyplexinol
• Promotes bone formation  and reduces bone resorption
• Improves bone mineral density even in ovariectomized rats
• Improves bone mass caused by estrogen decline
• Improves trabecular bone architecture,  trabecular thickness,  and trabecular connectivity
• Important morphogens with pleiotropic functions

Mechanisms of action:

• Bone and Cartilage: Osteoinductive effect (stimulating new bone formation)
  Bone Morphogenetic Proteins stimulate mesenchymal stem cells and differentiate them into osteoblasts (produce bone) and chondrocytes (produce cartilage).

• Arthritis (rheumatoid and osteo):   Anti-inflammatory effect
  Bone Morphogenetic Proteins have an antagonistic effect towards key pro-inflammatory cytokines (such as IL-1 and IL-6) and transcription factors all which are responsible for inflammation. BMPs have been studied for both rheumatoid and osteoarthritis (these patients are low in BMPs).

TRF 150’s Cyplexinol™ is also involved in the maintenance and repair of articular cartilage, which covers the surface of a joint where the ends of bones meet. When this cartilage becomes damaged, the bones will grind against each other instead of having a smooth, fluid movement. Since there is no direct blood supply to cartilage, damage to these areas from injuries, misuse, or overuse leads to pain and inflammation with potentially extended recovery time.