Due to its crystalline structure, absorption of DIM when given orally simply as a powder in a capsule is minimal, similar to CoQ10. DIM absorption can be greatly enhanced by emulsifying it with lecithin in rice bran oil, including with it compounds that hold it in solution such as beeswax, and finally adding fat-soluble nutrients that aid absorption through the gut wall. DIM-Avail is a unique combination of such ingredients. DIM-Avail uses the same proven technology of Designs for Health's Q-Avail, recently shown in human subjects to have far superior bioavailability and peak absorption rates in comparison to powdered CoQ10 and sublingual forms. Patients should expect to get therapeutic results taking DIM-Avail at the recommended dose of 1softgel per day, taken with a meal. Research tells us that a low level of the 2-hydroxyestrone and a high level of 16 alpha-hydroxyestrone is associated with an enhanced risk of breast cancer. DIM increases 2-hydroxyestrone and therefore improves the 2/16 hydroxyestrone ratio, making it very protective for women and men at high risk for this condition. Research by Bradlow has shown that DIM also reduces availability of 4-androstenedione for aromatization to estrone, a more dangerous form of estrogen. He concludes that DIM is more potent than I3C at protecting against breast cancer due to decreased formation of 16 alpha-hydroxyestrone from estrone. DIM supplementation improves the estrogen ratio in a favorable direction that protects both men and women without the negative effect of raising 4 hydroxyestrogen as seen with I3C. DIM does not block ovulation the way I3C does, and can be used safely along with Tamoxifen, unlike I3C. DIM should be considered first line therapy for hormone imbalances that can lead to negative conditions such as PMS, PCOS, endometriosis, fibroid tumors, menopausal symptoms, weight problems and the list goes on. Recent research is positive so far that DIM improves weight loss resistance due to hormonal imbalance.